[Effect of several m-cholinoblockaders on the functioning of sodium potential-dependent channels of neuroblastoma cells].

Abstract

Effects of two central antimuscarinic drugs, namely N-methyl-4-piperidinol benzylate and tropine phenylcyclopentylglycolate on Na currents in internally dialyzed mouse neuroblastoma cells were studied using the suction-pipette voltage-clamp technique. Like amine local anesthetics, the both compounds produce two phenomenologically different types of sodium current inhibition: a steady block without conditioning and a cumulative (use-dependent) block which develops during repetitive membrane pulsing. The ability of these m-cholinoblockers to modulate voltage-dependent ionic permeability of the neuronal membranes is supposed to be one of possible components in the mechanism of their both main and accessory (non-synaptic) effects.

• Authors: A N Zubov, I I Grishchenko, E D Nosyreva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1989 Jul-Aug Vol. 52 Issue 4 Pg. 17-20 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie nekotorykh m-kholinoblokatorov na funktsionirovanie natrievykh potentsialzavisimykh kanalov kletok neĭroblastomy.
• PMID: 2553477 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Parasympatholytics
• Sodium Channels

Topics

• Animals
• Cell Membrane Permeability (drug effects)
• Mice
• Neuroblastoma (metabolism)
• Neurons (drug effects)
• Parasympatholytics (pharmacology)
• Sodium Channels (drug effects)
• Tumor Cells, Cultured (drug effects, metabolism)