Rapid detection of hydrazine in a naphthol-fused chromenyl loop and its effectiveness in human lung cancer cells: tuning remarkable selectivity via the reaction altered pathway supported by theoretical studies.

Abstract

Our designed and synthesized chemosensor naphthalene based chromenyl derivative (NAC) [1-(3-hydroxy-3 methyl-3H-benzo[f]chromen-2-yl) ethanone] has been used for fast (<30 s, DL = 0.22 ppb) and selective detection of N2H4 by a new way via the chromenyl ring opening followed by the pyrazole ring formation giving a strong blue fluorescence. The DFT study and the real application in different water samples along with the dipstick method in low cost devices have also been performed here. Human lung cancer cells (NCI-H460) have been used for hydrazinolysis of the NAC in vivo system for detection by the appearance of blue fluorescence and also for the MTT assay showing its remarkable cancer sensitivity.

• Authors: Shyamaprosad Goswami, Avijit Kumar Das, Urmila Saha, Sibaprasad Maity, Kalyani Khanra, Nandan Bhattacharyya
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 13 Issue 7 Pg. 2134-9 (Feb 21 2015) ISSN: 1477-0539 [Electronic] England
• PMID: 25530298 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromones
• Hydrazines
• Naphthols
• hydrazine

Topics

• Chromones (chemical synthesis, chemistry)
• Humans
• Hydrazines (analysis)
• Lung Neoplasms (chemistry, pathology)
• Molecular Structure
• Naphthols (chemistry)
• Quantum Theory
• Spectrometry, Fluorescence