Abstract | BACKGROUND: STUDY DESIGN: Diagnostic test study. SETTINGS & PARTICIPANTS: PD patients who developed EPS were compared with controls using a 1:3 case-control design with a minimum PD duration of 57 months. INDEX TESTS: REFERENCE TEST: EPS cases identified by 2 experienced nephrologists and a radiologist based on predefined criteria. RESULTS: 11 patients developed EPS within our center. The time course of MMP-2 appearance rates, studied by means of a linear repeated-measures model 4 years prior to the diagnosis of EPS, showed no difference between long-term controls and patients with EPS. In contrast, higher PAI-1 appearance rates were found in patients with EPS compared with controls (P=0.01). At a lag time of 1 year prior to EPS diagnosis, time-specific receiver operating characteristic curve analyses indicated a discriminative ability for PAI-1 appearance rate of 0.77 (95% CI, 0.63-0.91). A discriminative capacity was absent for those of MMP-2. LIMITATIONS: Low event rate of EPS prevented independent validation in this single-center study. CONCLUSIONS:
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Authors | Deirisa Lopes Barreto, Dirk G Struijk, Raymond T Krediet |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 65
Issue 5
Pg. 748-53
(May 2015)
ISSN: 1523-6838 [Electronic] United States |
PMID | 25530106
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Dialysis Solutions
- Plasminogen Activator Inhibitor 1
- Matrix Metalloproteinase 2
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Topics |
- Adult
- Aged
- Biomarkers
(analysis)
- Dialysis Solutions
(chemistry)
- Female
- Humans
- Male
- Matrix Metalloproteinase 2
(analysis)
- Middle Aged
- Peritoneal Dialysis
(adverse effects)
- Peritoneal Fibrosis
(diagnosis, etiology)
- Plasminogen Activator Inhibitor 1
(analysis)
- Young Adult
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