[Activation of the interferon system enzymes by recombinant alpha2-interferon in patients with chronic hepatitis B].

Abstract

Treatment of patients suffering from chronic hepatitis B with recombinant leukocytic interferon (reaferon) increased the levels of circulating interferon and activated interferon-dependent enzymes such as 2-5A-synthetase and histone kinase. Activation of the enzymes was observed for 1 to 2 weeks. After that period it was maintained at the required levels with intramuscular administration of 1-3 million units of reaferon 2 or 3 times a week. In parallel with increasing of the levels of the interferon system enzymes there was observed a decrease in the level of aminotransferase. The reaction of the viral antigens to the treatment with reaferon was not the same: HBe antigen and antibodies to HBe antigen disappeared, the content of HBs antigen and antibodies to delta-interferon did not change.

• Authors: T M Sokolova, N P Bugaeva, I A Suetina, F I Ershov, E S Ketiladze
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 34 Issue 6 Pg. 472-5 (Jun 1989) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Aktivatsiia rekombinantnym alpha2-interferonom fermentov sistemy interferona u bol'nykh khronicheskim gepatitom B.
• PMID: 2552947 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Surface Antigens
• Hepatitis B e Antigens
• Interferon Type I
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Protamine Kinase
• 2',5'-Oligoadenylate Synthetase

Topics

• 2',5'-Oligoadenylate Synthetase (metabolism)
• Chronic Disease
• Enzyme Activation
• Hepatitis B (enzymology, therapy)
• Hepatitis B Surface Antigens (metabolism)
• Hepatitis B e Antigens (metabolism)
• Humans
• Interferon Type I (therapeutic use)
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Protamine Kinase (metabolism)
• Recombinant Proteins