Abstract | BACKGROUND: The choice of drugs for treatment of advanced gastric cancer (GC) is empirical. The purpose of the current study was to benchmark ex vivo the sensitivity of GC tumor cells from patients to standard cytotoxic and some newly introduced targeted drugs ( TDs), as a basis for drug selection in the treatment of GC. METHODS: RESULTS: The GC samples were essentially as sensitive to the standard drugs and the TDs as those from colorectal cancer whereas the ovarian cancer samples were more sensitive. The individual GC samples varied considerably in sensitivity to increasing concentrations of the clinically used standard drugs. In GC, cisplatin was cross-resistant to oxaliplatin and 5-fluorouracil which, on the other hand, was not cross-resistant to the other cytotoxic drugs. The activity of sunitinib did not obviously correlate to that of the standard drugs. CONCLUSION: Ex vivo assessment of drug sensitivity of tumor cells from patients with GC is feasible and may provide information that could be useful for selection of drugs for treatment. Drug sensitivity varies considerably between and within individual samples arguing for individualized selection of drugs for chemotherapy.
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Authors | Bo Hultman, Haile Mahteme, Magnus Sundbom, Martin Ljungman, Rolf Larsson, Peter Nygren |
Journal | Journal of experimental & clinical cancer research : CR
(J Exp Clin Cancer Res)
Vol. 33
Pg. 110
(Dec 21 2014)
ISSN: 1756-9966 [Electronic] England |
PMID | 25528067
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Benchmarking
(standards)
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
(standards)
- Feasibility Studies
- Female
- Humans
- Male
- Medical Oncology
(standards)
- Middle Aged
- Molecular Targeted Therapy
(standards)
- Patient Selection
- Predictive Value of Tests
- Stomach Neoplasms
(drug therapy, pathology)
- Tumor Cells, Cultured
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