OPC-88117 suppresses early and delayed afterdepolarizations and arrhythmias induced by cesium, 4-aminopyridine and digitalis in canine Purkinje fibers and in the canine heart in situ.

Abstract

The effects of OPC-88117, a new investigational antiarrhythmic drug, on early and delayed afterdepolarizations (EAD and DAD, respectively) were assessed in vitro in canine Purkinje fibers and in vivo in the canine right ventricle. OPC-88117 had similar electrophysiologic properties to class I antiarrhythmic agents in that it decreased Vmax. OPC-88117 decreased the amplitude and prolonged the coupling interval of DAD induced by acetylstrophanthidin. Likewise, OPC-88117 suppressed EAD induced in vitro by 4-aminopyridine. In vivo, cesium-induced EAD, ventricular arrhythmia, and atrioventricular block were suppressed by OPC-88117. In summary, OPC-88117 suppressed DAD and EAD in vitro and inhibited EAD and triggered activity in the in situ canine heart.

• Authors: B Graham, R F Gilmour Jr, M S Stanton, D P Zipes
• Journal: American heart journal (Am Heart J) Vol. 118 Issue 4 Pg. 708-16 (Oct 1989) ISSN: 0002-8703 [Print] United States
• PMID: 2552784 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cardiovascular Agents
• Piperazines
• Quinolones
• 8-methyl-3-(4-methyl-1-piperazinyl)-2(1H)-quinolinone
• Cesium
• 4-Aminopyridine

Topics

• 4-Aminopyridine
• Action Potentials (drug effects)
• Animals
• Arrhythmias, Cardiac (chemically induced, drug therapy, physiopathology)
• Cardiovascular Agents
• Cesium
• Digitalis
• Dogs
• Electrocardiography
• Heart (drug effects)
• Heart Block (prevention & control)
• Heart Conduction System
• Membrane Potentials (drug effects)
• Piperazines (pharmacology)
• Plants, Medicinal
• Plants, Toxic
• Purkinje Fibers (drug effects)
• Quinolones (pharmacology)