The effects of CA1 5HT4 receptors in MK801-induced amnesia and hyperlocomotion.

Abstract

In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 (62.5 and 625 ng/mouse) and RS23597 (1 and 10 ng/mouse) decreased memory consolidation, but it did not alter head-dip counts, head-dip latency and locomotor activity. Similarly, MK801 (0.5 and 1 μg/mouse) decreased memory consolidation, but had no effect on head-dip counts and head-dip latency. Interestingly, it increased locomotor activity. The results also showed that post-training intra-CA1 injection of a sub-threshold dose of RS67333 (6.25 ng/mouse) or RS23597 (0.1 ng/mouse) could heighten MK801 induced amnesia and decrease locomotor activity, but it did not alter head-dip counts and head-dip latency. In conclusion, our findings suggest that the CA1 5-HT4 receptors are involved in MK801-induced amnesia and hyperlocomotion.

• Authors: Mohammad Nasehi, Maryam Tabatabaie, Fatemeh Khakpai, Mohammad-Reza Zarrindast
• Journal: Neuroscience letters (Neurosci Lett) Vol. 587 Pg. 73-8 (Feb 05 2015) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 25524640 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• 3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
• Aniline Compounds
• Piperidines
• Receptors, N-Methyl-D-Aspartate
• Serotonin 5-HT4 Receptor Agonists
• Serotonin 5-HT4 Receptor Antagonists
• para-Aminobenzoates
• Receptors, Serotonin, 5-HT4
• RS 67333
• Dizocilpine Maleate

Topics

• Amnesia (chemically induced, metabolism, psychology)
• Aniline Compounds (pharmacology)
• Animals
• CA1 Region, Hippocampal (metabolism)
• Dizocilpine Maleate (toxicity)
• Drug Partial Agonism
• Exploratory Behavior (drug effects)
• Male
• Memory (drug effects)
• Mice
• Motor Activity (drug effects)
• Piperidines (pharmacology)
• Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)
• Receptors, Serotonin, 5-HT4 (metabolism)
• Serotonin 5-HT4 Receptor Agonists (pharmacology)
• Serotonin 5-HT4 Receptor Antagonists (pharmacology)
• para-Aminobenzoates (pharmacology)