Protective effect ofAgave salmiana fructans in azoxymethane- induced colon cancer in Wistar rats.

Abstract

Colon cancer is a world concerning disease; it shows a high mortality rate and may be related to eating habits. Studies using inulin-like fructans, which are produced as energy supplies by several plants, have demonstrated a chemo-protective effect of these fructans in colon cancer. However, agavins a structurally different type of fructans from the Agave genus with demonstrated prebiotic effects, have been poorly studied for their possible protective effects in cancer. The aim of the present study was to evaluate the effect ofAgave fructan-rich diets in colon cancer progress using a rat model and "Agave mezcalero potosino" A. salmiana Otto ex Salm Dick, which is widely distributed in Mexico. Results showed a significant decrease (p<0.05) in early lesions of colon cancer (aberrant crypt foci) compared with the control group. These data suggest that fructans from A. salmiana may contribute to a reduction in the risk of colon cancer as well as inulin-like compounds.

• Authors: Antonio Dávila-Céspedes, Bertha I Juárez-Flores, Juan M Pinos-Rodríguezc, Juan R Aguirre-Riverab, A Cuahutemoc Oros-Ovalled, E D Loyola-Martínez, Hera Andrade-Zaldívar
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 10 Pg. 1503-6 (Oct 2014) ISSN: 1934-578X [Print] United States
• PMID: 25522547 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Fructans
• Azoxymethane

Topics

• Agave (chemistry)
• Animals
• Antineoplastic Agents (chemistry, therapeutic use)
• Azoxymethane (toxicity)
• Colonic Neoplasms (chemically induced, drug therapy)
• Fructans (chemistry, therapeutic use)
• Rats
• Rats, Wistar