Abstract | BACKGROUND:
Antidepressants (ADs) are known to have the potential to cause various cardiovascular adverse drug reactions (ADRs). The tricyclic antidepressants (TCAs) were first revealed to be a possible source of cardiovascular ADRs. In recent years, newer classes of ADs were also suggested to have a higher risk of cardiovascular adverse effects. In particular, the selective serotonin reuptake inhibitors ( SSRIs) were suspected to have the potential to induce QTc interval prolongation, and therefore increase the risk of ventricular arrhythmia. This descriptive study is based on the continuous pharmacovigilance program of German-speaking countries (Austria, Germany, and Switzerland), the Arzneimittelsicherheit in der Psychiatrie (AMSP), which assesses severe ADRs occurring in clinical routine situations. METHODS: Of 169,278 psychiatric inpatients treated with ADs between 1993 and 2010, 198 cases of cardiovascular ADRs (0.12%) were analyzed. RESULTS: CONCLUSIONS: Despite certain limitations due to the AMSP study design, our observations on cardiovascular ADRs can contribute to a better knowledge of the cardiovascular risk profiles of antidepressants in the clinical routine setting. However, prospective studies are needed to verify our findings.
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Authors | Christoph Josef Spindelegger, Konstantinos Papageorgiou, Renate Grohmann, Rolf Engel, Waldemar Greil, Anastasios Konstantinidis, Marcus Willy Agelink, Stefan Bleich, Eckart Ruether, Sermin Toto, Siegfried Kasper |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 18
Issue 4
(Oct 31 2014)
ISSN: 1469-5111 [Electronic] England |
PMID | 25522416
(Publication Type: Journal Article)
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Copyright | © The Author 2015. Published by Oxford University Press on behalf of CINP. |
Chemical References |
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Topics |
- Adverse Drug Reaction Reporting Systems
- Aged
- Antidepressive Agents
(adverse effects, therapeutic use)
- Austria
(epidemiology)
- Cardiovascular Diseases
(chemically induced, epidemiology)
- Female
- Germany
(epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Switzerland
(epidemiology)
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