Abstract | BACKGROUND: METHODS: We used secondary data from the Baltimore-Washington Infant Study (1981-1989). Mediation analysis was employed to investigate whether gestational age acted as a mediator of the association between CHD and reduced birth-weight. We estimated the mediated effect, the mediation proportion, and their corresponding 95% confidence intervals (CI) using several methods. RESULTS: There were 3362 CHD cases and 3564 controls in the dataset with mean birth-weight of 3071 (SD = 729) and 3353 (SD = 603) grams, respectively; the mean gestational age was 38.9 (SD = 2.7) and 39.6 (SD = 2.2) weeks, respectively. After adjusting for covariates, the estimated mediated effect by gestational age was 113.5 grams (95% CI, 92.4-134.2) and the mediation proportion was 40.7% (95% CI, 34.7%-46.6%), using the bootstrap approach. CONCLUSIONS: Gestational age may account for about 41% of the overall effect of heart defects on reduced infant birth-weight. Improved prenatal care and other public health efforts that promote full term delivery, particularly targeting high-risk families and mothers known to be carrying a fetus with CHD, may therefore be expected to improve the birth-weight of these infants and their long term health.
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Authors | Adane F Wogu, Christopher A Loffredo, Ionut Bebu, George Luta |
Journal | BMC research notes
(BMC Res Notes)
Vol. 7
Pg. 926
(Dec 17 2014)
ISSN: 1756-0500 [Electronic] England |
PMID | 25515761
(Publication Type: Journal Article)
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Topics |
- Adult
- Birth Weight
- Case-Control Studies
- District of Columbia
(epidemiology)
- Educational Status
- Female
- Gestational Age
- Heart Defects, Congenital
(epidemiology)
- Humans
- Infant
- Infant, Newborn
- Male
- Maryland
(epidemiology)
- Maternal Age
- Mothers
- Risk Assessment
(methods, statistics & numerical data)
- Risk Factors
- Smoking
- Virginia
(epidemiology)
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