Abstract | BACKGROUND: Novel treatments against for tinea capitis are needed, and the natural aminosterol squalamine is a potential topical antidermatophyte drug candidate. OBJECTIVES: This phase II randomized double-blind placebo-controlled clinical trial aimed at testing the efficacy and safety of a three-week squalamine ointment regimen for the treatment of tinea capitis. PATIENTS: Males aged 6-15 years presenting with tinea capitis were treated with either topical squalamine ointment or placebo for 3 weeks. The primary endpoint was complete clinical cure. The secondary endpoints were the occurrence of local and/or systemic adverse events, mycological cure, and partial clinical response. Prospective follow-up of clinical adverse events was performed daily. RESULTS: Five patients were treated with 1% squalamine ointment and 15 with placebo. No complete cure was observed. No clinical or biological adverse event was recorded. A significantly (p = 0.03) better hair-growth score, indicating a partial clinical improvement of the tinea capitis lesion, was observed in the patients treated with squalamine compared to those treated with placebo. CONCLUSION:
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Authors | Oumar Coulibaly, Mahamadou A Thera, Abdoulaye K Koné, Goïta Siaka, Pierre Traoré, Abdoulaye A Djimdé, Jean-Michel Brunel, Jean Gaudart, Renaud Piarroux, Ogobara K Doumbo, Stéphane Ranque |
Journal | Mycopathologia
(Mycopathologia)
Vol. 179
Issue 3-4
Pg. 187-93
(Apr 2015)
ISSN: 1573-0832 [Electronic] Netherlands |
PMID | 25515244
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antifungal Agents
- Cholestanols
- Ointments
- squalamine
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Topics |
- Administration, Topical
- Adolescent
- Antifungal Agents
(administration & dosage, adverse effects)
- Arthrodermataceae
(classification, drug effects, genetics, isolation & purification)
- Blood Cell Count
- Child
- Cholestanols
(administration & dosage, adverse effects)
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Male
- Ointments
(administration & dosage, adverse effects)
- Tinea Capitis
(blood, drug therapy, microbiology)
- Treatment Outcome
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