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Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?

Abstract
Metabolic reprogramming is a characteristic of cancer cells. Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit.
AuthorsPeter W Szlosarek, SukJun Lee, Patrick J Pollard
JournalMolecular cell (Mol Cell) Vol. 56 Issue 3 Pg. 343-4 (Nov 6 2014) ISSN: 1097-4164 [Electronic] United States
PMID25514180 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Pyruvic Acid
Topics
  • Biological Transport
  • Glycolysis
  • Humans
  • Mitochondria (metabolism)
  • Molecular Targeted Therapy
  • Neoplasms (drug therapy, metabolism, pathology)
  • Pyruvic Acid (metabolism)

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