[Molecular markers: an important tool in the diagnosis, treatment and epidemiology of invasive aspergillosis].

Increase in the incidence of invasive aspergillosis has represented a difficult problem for management of patients with this infection due to its high rate of mortality, limited knowledge concerning its diagnosis, and therapeutic practice. The difficulty in management of patients with aspergillosis initiates with detection of the fungus in the specimens of immunosuppressed patients infected with Aspergillus fumigatus; in addition, difficulty exists in terms of the development of resistance to antifungals as a consequence of their indiscriminate use in prophylactic and therapeutic practice and to ignorance concerning the epidemiological data of aspergillosis. With the aim of resolving these problems, molecular markers is employed at present with specific and accurate results. However, in Mexico, the use of molecular markers has not yet been implemented in the routine of intrahospital laboratories; despite the fact that these molecular markers has been widely referred in the literature, it is necessary for it to validated and standardized to ensure that the results obtained in any laboratory would be reliable and comparable. In the present review, we present an update on the usefulness of molecular markers in accurate identification of A. fumigatus, detection of resistance to antifugal triazoles, and epidemiological studies for establishing the necessary measures for prevention and control of aspergillosis.
AuthorsMaría Guadalupe Frías-de León, Gustavo Acosta-Altamirano, Esperanza Duarte-Escalante, José Enrique Martínez-Hernández, María de Los Ángeles Martínez-Rivera, María Del Rocío Reyes-Montes
JournalCirugía y cirujanos (Cir Cir) 2014 Jan-Feb Vol. 82 Issue 1 Pg. 109-18 ISSN: 0009-7411 [Print] Mexico
Vernacular TitleMarcadores moleculares: una herramienta importante en el diagnóstico, tratamiento y epidemiología de la aspergilosis invasora.
PMID25510798 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Antifungal Agents
  • DNA, Fungal
  • Animals
  • Antifungal Agents (therapeutic use)
  • Aspergillosis (blood, diagnosis, drug therapy, epidemiology)
  • Aspergillus fumigatus (drug effects, genetics, immunology)
  • DNA, Fungal (blood)
  • Drug Monitoring
  • Drug Resistance, Multiple, Fungal (genetics)
  • Fungemia (blood, diagnosis, drug therapy)
  • Gene Amplification
  • Genes, Fungal
  • HIV Infections (complications, immunology)
  • Humans
  • Mexico (epidemiology)
  • Mice
  • Molecular Diagnostic Techniques (methods)
  • Mycological Typing Techniques
  • Neoplasms (complications, immunology)
  • Opportunistic Infections (blood, diagnosis, drug therapy)

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