Abstract | PURPOSE: This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure ( APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment. METHODS: Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software. RESULTS: After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence. CONCLUSIONS: Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.
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Authors | Sandra Rebelo, Marta Drummond, José Agostinho Marques |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 19
Issue 3
Pg. 931-7
(Sep 2015)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 25510508
(Publication Type: Journal Article)
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Chemical References |
- Hypolipidemic Agents
- Lipids
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Topics |
- Adult
- Aged
- Combined Modality Therapy
- Continuous Positive Airway Pressure
- Dyslipidemias
(blood, therapy)
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Lipids
(blood)
- Male
- Middle Aged
- Multivariate Analysis
- Polysomnography
(drug effects)
- Prospective Studies
- Sleep Apnea, Obstructive
(blood, therapy)
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