HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lipid profile after long-term APAP in OSA patients.

AbstractPURPOSE:
This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.
METHODS:
Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.
RESULTS:
After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.
CONCLUSIONS:
Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.
AuthorsSandra Rebelo, Marta Drummond, José Agostinho Marques
JournalSleep & breathing = Schlaf & Atmung (Sleep Breath) Vol. 19 Issue 3 Pg. 931-7 (Sep 2015) ISSN: 1522-1709 [Electronic] Germany
PMID25510508 (Publication Type: Journal Article)
Chemical References
  • Hypolipidemic Agents
  • Lipids
Topics
  • Adult
  • Aged
  • Combined Modality Therapy
  • Continuous Positive Airway Pressure
  • Dyslipidemias (blood, therapy)
  • Humans
  • Hypolipidemic Agents (therapeutic use)
  • Lipids (blood)
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polysomnography (drug effects)
  • Prospective Studies
  • Sleep Apnea, Obstructive (blood, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: