Abstract | AIM: METHOD: Two major databases (PubMed and Cochrane) were searched using predefined terms. All original articles, published in English, comparing the oncological outcomes of SC and TC in HNPCC patients from January 1950 to July 2013 were included. RESULTS: Eighty-four studies were identified. After applying exclusion criteria, six studies involving 948 patients were included (mean age 47.4 years, 51.8% male). SC was more commonly performed than TC (n = 780; 82.3%). Mean follow-up was 106.5 months. Metachronous high-risk adenomas were detected more often after SC, although the difference was not statistically significant (23.4% vs 9.6%; OR 2.258, P = 0.057). Metachronous cancers occurred more frequently after SC than after TC (23.5% vs 6.8%; OR 3.679, P < 0.005). However, there was no difference in overall survival (90.7% vs 89.8% for SC and TC, respectively; P = 0.085). Only one study reported operative mortality (0% in each group), there was no report of operative morbidity or functional outcome. CONCLUSION: The optimal surgical approach in the management of HNPCC remains unclear. More adenomas and cancers occur after SC than after TC but there certainly is no evidence to suggest that more radical surgery leads to improved survival.
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Authors | H M Heneghan, S T Martin, D C Winter |
Journal | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
(Colorectal Dis)
Vol. 17
Issue 5
Pg. 382-9
(May 2015)
ISSN: 1463-1318 [Electronic] England |
PMID | 25510173
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland. |
Topics |
- Adenocarcinoma
(surgery)
- Adenoma
(surgery)
- Colectomy
(methods)
- Colorectal Neoplasms, Hereditary Nonpolyposis
(surgery)
- Disease Management
- Humans
- Neoplasm Recurrence, Local
(prevention & control)
- Prophylactic Surgical Procedures
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