Coapplication of lidocaine and membrane-impermeable lidocaine derivative QX-222 produces divergent effects on evoked and spontaneous nociceptive behaviors in mice.

Abstract

The present study was aimed at investigating the analgesic properties of a combination of lidocaine and QX-222 and its effects on evoked pain behavior (complete Freund's adjuvant-induced allodynia and hyperalgesia in inflammatory condition) and spontaneous pain behavior (formalin-induced acute pain) in mice. Drugs were injected adjacent to sciatic nerve or into plantar. Motor function, thermal withdrawal latency, mechanical withdrawal threshold, and licking/biting were evaluated by behavioral tests. A combination of lidocaine and QX-222 adjacent sciatic nerve injection produced the long-lasting sensory-specific nerve block, and intraplantar injection inhibited spontaneous pain in the formalin-treated mice but did not detectably attenuated hyperalgesia and allodynia in the complete Freund's adjuvant- (CFA-) treated mice. Our results suggest that a combination of lidocaine and QX-222 achieves a long-lasting differential block (sensory selective) and produces divergent effects on evoked and spontaneous pain behaviors in mice.

• Authors: Si-Ping Hu, Jing-Jing Zhao, Wei-Xing Wang, Yang Liu, He-Fen Wu, Chao Chen, Liang Yu, Jing-Bing Gui
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 628729 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25506595 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Drug Combinations
• QX-222
• Lidocaine

Topics

• Analgesics
• Animals
• Behavior, Animal (drug effects)
• Drug Combinations
• Humans
• Lidocaine (administration & dosage, analogs & derivatives)
• Mice
• Nociception (drug effects)
• Pain (drug therapy)
• Pain Measurement
• Sciatic Nerve (drug effects)