Abstract | BACKGROUND: METHODS: This was a prospective cross-sectional study. Clinical data and blood samples were collected from adults in Mozambique. Plasma was analysed for 21 classical pro- and anti-inflammatory cytokines, including interleukins, interferons, and chemokines. RESULTS: We included 212 in-patients with fever and/or suspected malaria and 56 healthy controls. Falciparum malaria was diagnosed in 131 patients, of whom 70 were co-infected with HIV-1. The malaria patients had marked increases in their cytokine responses compared with the healthy controls. Some of these changes, particularly interleukin 8 (IL-8) and interferon-γ-inducing protein 10 (IP-10) were strongly associated with falciparum malaria and disease severity. Both these chemokines were markedly increased in patients with falciparum malaria as compared with healthy controls, and raised levels of IL-8 and IP-10 were associated with increased disease severity, even after adjusting for relevant confounders. For IL-8, particularly high levels were found in malaria patients that were co-infected with HIV and in those who died during hospitalization. INTERPRETATIONS: Our findings underscore the complex role of inflammation during infection with P. falciparum, and suggest a potential pathogenic role for IL-8 and IP-10. However, the correlations do not necessarily mean any causal relationship, and further both clinical and mechanistic research is necessary to elucidate the role of cytokines in pathogenesis and protection during falciparum malaria.
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Authors | Aase Berg, Sam Patel, Miguel Gonca, Catarina David, Kari Otterdal, Thor Ueland, Ingvild Dalen, Jan T Kvaløy, Tom E Mollnes, Pål Aukrust, Nina Langeland |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 12
Pg. e114480
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25503583
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CXCL10 protein, human
- Chemokine CXCL10
- Interleukin-8
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Topics |
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Chemokine CXCL10
(metabolism)
- Coinfection
(metabolism, mortality)
- Female
- HIV Infections
(metabolism, mortality)
- HIV-1
(physiology)
- Hospitals
(statistics & numerical data)
- Humans
- Interleukin-8
(metabolism)
- Malaria, Falciparum
(metabolism, mortality)
- Male
- Middle Aged
- Mozambique
(epidemiology)
- Young Adult
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