Enhanced in vivo delivery of 5-fluorouracil by ethosomal gels in rabbit ear hypertrophic scar model.
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| Abstract |
Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 ± 1 °C had a better size stability than that at 25 ± 1 °C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future.
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| Authors | Yan Wo, Zheng Zhang, Yixin Zhang, Zhen Zhang, Kan Wang, Xiaohui Mao, Weijie Su, Ke Li, Daxiang Cui, Jun Chen |
| Journal | International journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 12 Pg. 22786-800 (Dec 09 2014) ISSN: 1422-0067 [Electronic] Switzerland |
| PMID | 25501333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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