Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures.

Abstract

Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.

• Authors: G Gandolfo, C Gottesmann, J N Bidard, M Lazdunski
• Journal: Brain research (Brain Res) Vol. 495 Issue 1 Pg. 189-92 (Aug 21 1989) ISSN: 0006-8993 [Print] Netherlands
• PMID: 2550110 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminopyridines
• Elapid Venoms
• Neurotoxins
• Peptides
• Potassium Channels
• mast cell degranulating peptide
• dendrotoxin
• 4-Aminopyridine

Topics

• 4-Aminopyridine
• Aminopyridines (pharmacology)
• Animals
• Elapid Venoms (pharmacology)
• Injections, Intraventricular
• Male
• Neurotoxins (pharmacology)
• Peptides (pharmacology)
• Potassium Channels (classification, drug effects, physiology)
• Rats
• Rats, Inbred Strains
• Seizures (chemically induced, metabolism)