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Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
The species Sparattosperma leucanthum (Vell.) K. Schum is used in Brazilian folk medicine to treat rheumatism, throat ulcers, stomatitis, syphilis, bladder stones and as blood cleanser. The aim of this study was to evaluate the potential, in vitro and in vivo, of the extracts of leaves from Sparattosperma leucanthum to treat hyperuricemia and inflammation in the gouty arthritis model.
MATERIALS AND METHODS:
Ethyl acetate extract (SLE), methanolic extract (SLM) and aqueous extract (SLW) were evaluated in vitro on XO inhibitory activity and in vivo in an experimental model with oxonate-induced hyperuricemia in mice which was used to evaluate anti-hyperuricemic activity and liver xanthine oxidase (XOD) inhibition. Anti-inflammatory activity was also investigated on MSU crystal-induced paw edema model.
RESULTS:
Sparattosperma leucanthum crude extracts showed expressive results on urate-lowering activity in blood. SLW at the dose of 125 mg/kg has proved to be active in reducing hyperuricemia and was capable to inhibit the hepatic xanthine oxidase enzyme (XOD). SLM showed anti-hyperuricemic activity on all doses tested; however, this extract showed activity on the XOD only at the dose of 500 mg/kg. SLE, at the three evaluated doses, has proved to be active in reducing hyperuricemia in vivo and was able to inhibit XO activity in vitro at the concentration of 100 µg/mL. This extract was also able to inhibit XOD activity in vivo at the doses of 250 mg/kg and 500 mg/kg. SLE (125 and 250 mg/kg) and SLW (500 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model.
CONCLUSIONS:
The ethyl acetate, methanolic and aqueous extracts of Sparattosperma leucanthum showed significant results on evaluated models and therefore may be important agents for the treatment of gouty arthritis and hyperuricemia.
AuthorsRita de Cássia Lemos Lima, Fernanda Cristina Ferrari, Maíra Ribeiro de Souza, Bruna Maria de Sá Pereira, Carmen Aparecida de Paula, Dênia Antunes Saúde-Guimarães
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 161 Pg. 194-9 (Feb 23 2015) ISSN: 1872-7573 [Electronic] Ireland
PMID25500302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Gout Suppressants
  • Plant Extracts
  • Uric Acid
  • Oxonic Acid
  • Xanthine Oxidase
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Arthritis, Gouty (blood, drug therapy)
  • Bignoniaceae
  • Gout Suppressants (pharmacology, therapeutic use)
  • Hyperuricemia (blood, chemically induced, drug therapy)
  • Liver (drug effects, metabolism)
  • Male
  • Mice
  • Oxonic Acid
  • Phytotherapy
  • Plant Extracts (pharmacology, therapeutic use)
  • Plant Leaves
  • Uric Acid (blood)
  • Xanthine Oxidase (antagonists & inhibitors, metabolism)

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