Abstract | BACKGROUND: OBJECTIVE: We hypothesized that fasting TG would independently predict cardiorenal disease in adults with T1D and normal-to-low levels of TG. METHODS: Subjects (N = 652) were 19 to 56 years old at baseline and reexamined 6 years later. Urinary albumin excretion was measured, and categorized as microalbuminuria or greater. Progression of coronary artery calcification (CACp), measured using electron beam computed tomography, was defined as a change in the square root transformed CAC volume ≥2.5. The association of low-density lipoprotein cholesterol ( LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B, non-HDL-C, natural log triglyceride (lnTG), ln(TG/HDL-C) ratio with CACp and incident albuminuria were examined in logistic regression. The models were adjusted for age, sex, T1D duration, hemoglobin A1c, systolic blood pressure, diastolic blood pressure, blood pressure medications, statins, and smoking status. Integrated discrimination index and net reclassification improvement were used to examine prediction performance. RESULTS: Incident albuminuria was independently associated with CACp. lnTG independently predicted both incident albuminuria (odds ratio: 1.53, 1.02-2.30, P = .04) and CACp (1.41, 1.11-1.80, P = .006). The addition of lnTG to ABC risk factors (HbA1c, systolic blood pressure, diastolic blood pressure, and LDL-C) moderately improved discrimination and reclassification of CACp and incident albuminuria. CONCLUSION: In adults with T1D, fasting TG independently predicted cardiorenal disease over 6 years and improved reclassification of risk by conventional risk factors.
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Authors | Petter Bjornstad, David M Maahs, R Paul Wadwa, Laura Pyle, Marian Rewers, Robert H Eckel, Janet K Snell-Bergeon |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2014 Nov-Dec
Vol. 8
Issue 6
Pg. 576-583
ISSN: 1933-2874 [Print] United States |
PMID | 25499940
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoproteins
- Triglycerides
- Cholesterol
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Topics |
- Adult
- Albuminuria
(diagnosis, etiology)
- Apolipoproteins
(blood)
- Calcinosis
(diagnosis, etiology)
- Cholesterol
(blood)
- Coronary Vessels
(diagnostic imaging, pathology)
- Diabetes Mellitus, Type 1
(blood, complications)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Prognosis
- Tomography, X-Ray Computed
- Triglycerides
(blood)
- Young Adult
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