Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.

Abstract

Metabotropic glutamate receptors (mGluRs) modulate neurotransmission all along the pain neuraxis. While the involvement of group I and group II mGluRs in pain is well documented, information has only just started to emerge concerning the role and contribution of group III mGluRs subtypes to pain modulation. Recent data suggest that these receptors reduce symptoms in animal models of chronic pain, as well as regulate neurotransmission at different levels of ascending and descending pain pathway, suggesting that group III mGluRs may be interesting therapeutic targets for the development of analgesics.

• Authors: Francine Acher, Cyril Goudet
• Journal: Current opinion in pharmacology (Curr Opin Pharmacol) Vol. 20 Pg. 64-72 (Feb 2015) ISSN: 1471-4973 [Electronic] England
• PMID: 25498980 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Analgesics
• Ligands
• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor 3

Topics

• Analgesics (pharmacology)
• Animals
• Chronic Pain (drug therapy, physiopathology)
• Humans
• Ligands
• Molecular Targeted Therapy
• Pain (drug therapy, physiopathology)
• Receptors, Metabotropic Glutamate (drug effects, metabolism)
• Synaptic Transmission (physiology)