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Bovine adenovirus-3 as a vaccine delivery vehicle.

Abstract
The use of vaccines is an effective and relatively inexpensive means of controlling infectious diseases, which cause heavy economic losses to the livestock industry through animal loss, decreased productivity, treatment expenses and decreased carcass quality. However, some vaccines produced by conventional means are imperfect in many respects including virulence, safety and efficacy. Moreover, there are no vaccines for some animal diseases. Although genetic engineering has provided new ways of producing effective vaccines, the cost of production for veterinary use is a critical criterion for selecting the method of production and delivery of vaccines. The cost effective production and intrinsic ability to enter cells has made adenovirus vectors a highly efficient tool for delivery of vaccine antigens. Moreover, adenoviruses induce both humoral and cellular immune responses to expressed vaccine antigens. Since nonhuman adenoviruses are species specific, the development of animal specific adenoviruses as vaccine delivery vectors is being evaluated. This review summarizes the work related to the development of bovine adenovirus-3 as a vaccine delivery vehicle in animals, particularly cattle.
AuthorsLisanework E Ayalew, Pankaj Kumar, Amit Gaba, Niraj Makadiya, Suresh K Tikoo
JournalVaccine (Vaccine) Vol. 33 Issue 4 Pg. 493-9 (Jan 15 2015) ISSN: 1873-2518 [Electronic] Netherlands
PMID25498212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Drug Carriers
  • Vaccines, Attenuated
  • Vaccines, Synthetic
Topics
  • Animals
  • Cattle
  • Drug Carriers
  • Drug Discovery (trends)
  • Genetic Vectors
  • Immunity, Cellular
  • Immunity, Humoral
  • Mastadenovirus (genetics)
  • Vaccines, Attenuated (genetics, immunology)
  • Vaccines, Synthetic (genetics, immunology)
  • Veterinary Medicine (methods)

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