Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study.

Abstract

BACKGROUND:

Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. Indoor air pollution from use of indoor stoves and/or fireplaces is an important source of ambient PAH exposure. However, the association between indoor stove/fireplace use and breast cancer risk is unknown. We hypothesized that indoor stove/fireplace use in a Long Island, New York study population would be positively associated with breast cancer and differ by material burned, and the duration and timing of exposure. We also hypothesized that the association would vary by breast cancer subtype defined by p53 mutation status, and interact with glutathione S-transferases GSTM1, T1, A1 and P1 polymorphisms.

METHODS:

Population-based, case-control resources (1,508 cases/1,556 controls) were used to conduct unconditional logistic regression to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).

RESULTS:

Breast cancer risk was increased among women reporting ever burning synthetic logs (which may also contain wood) in their homes (OR = 1.42, 95% CI 1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95% CI 0.77, 1.12). For synthetic log use, longer duration >7 years, older age at exposure (>20 years; OR = 1.65, 95% CI 1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR = 1.71, 95% CI 1.09, 2.69) were associated with increased risk.

CONCLUSIONS:

Burning wood or synthetic logs are both indoor PAH exposure sources; however, positive associations were only observed for burning synthetic logs, which was stronger for longer exposures, adult exposures, and those with multiple GST variant genotypes. Therefore, our results should be interpreted with care and require replication.

• Authors: Alexandra J White, Susan L Teitelbaum, Steven D Stellman, Jan Beyea, Susan E Steck, Irina Mordukhovich, Kathleen M McCarty, Jiyoung Ahn, Pavel Rossner Jr, Regina M Santella, Marilie D Gammon
• Journal: Environmental health : a global access science source (Environ Health) Vol. 13 Pg. 108 (Dec 12 2014) ISSN: 1476-069X [Electronic] England
• PMID: 25495350 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Coal
• Natural Gas
• Receptors, Estrogen
• Receptors, Progesterone
• Tumor Suppressor Protein p53
• Glutathione Transferase

Topics

• Adult
• Aged
• Aged, 80 and over
• Air Pollution, Indoor (analysis)
• Breast Neoplasms (epidemiology, genetics, metabolism)
• Case-Control Studies
• Coal
• Cooking
• Environmental Exposure (analysis)
• Female
• Glutathione Transferase (genetics)
• Humans
• Middle Aged
• Mutation
• Natural Gas
• New York (epidemiology)
• Odds Ratio
• Polymorphism, Genetic
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Tumor Suppressor Protein p53 (genetics)
• Wood
• Young Adult