Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs.

Abstract

A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.

• Authors: Wang Xiao, Xuan Zeng, Hang Lin, Kai Han, Hui-Zhen Jia, Xian-Zheng Zhang
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 8 Pg. 1475-8 (Jan 28 2015) ISSN: 1364-548X [Electronic] England
• PMID: 25494173 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• Dextrans
• Polymers
• Rhodamines
• alpha-Cyclodextrins
• Matrix Metalloproteinases
• Fluorescein-5-isothiocyanate
• rhodamine B

Topics

• Antineoplastic Agents (administration & dosage)
• Cell Line, Tumor
• Delayed-Action Preparations
• Dextrans (administration & dosage, chemistry, radiation effects)
• Drug Delivery Systems
• Endocytosis
• Fluorescein-5-isothiocyanate (administration & dosage, chemistry, radiation effects)
• Humans
• Matrix Metalloproteinases (chemistry, metabolism, radiation effects)
• Polymers (chemistry)
• Rhodamines (administration & dosage, chemistry, radiation effects)
• Ultraviolet Rays
• alpha-Cyclodextrins (administration & dosage, chemistry, radiation effects)