Abstract |
The OmpR superfamily includes proteins that act as transcriptional regulators of operons that respond to environmental stimuli. A homologous domain near the N-terminus, termed a sensor-binding core domain, is thought to play a role in recognition of a signal transduction protein. We have identified two previously unrecognized members of this regulator family of proteins: a 23.8-kd protein transcribed from the uvrC transcription unit and the PgtA gene product, which is a phosphoglycerate transport regulatory protein. The sensor-binding core domain is also present in four proteins that regulate bacterial sporulation and chemotaxis. The 23.8-kd protein also has sequence similarity to elongation factor Tu and two regulatory proteins: HtpR, the heat-shock regulatory protein, and TraJ, a regulator of expression of genes involved in conjugation. There is a 77-amino acid region near the C-terminus of the 23.8-kd protein that has 30% similarity with a 28.1-kd protein coded for by an open reading frame 5' to the reading frame of the 23.8-kd protein in the uvrC transcription unit. Genetic distance analysis of amino acid sequences of proteins with a sensor-binding core domain suggests that the 23.8-kd protein and the chemotaxis regulatory proteins are distantly related to the other regulatory proteins in the OmpR superfamily.
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Authors | T L Timme, C B Lawrence, R E Moses |
Journal | Journal of molecular evolution
(J Mol Evol)
Vol. 28
Issue 6
Pg. 545-52
(Jun 1989)
ISSN: 0022-2844 [Print] Germany |
PMID | 2549258
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
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Topics |
- Amino Acid Sequence
- Bacterial Outer Membrane Proteins
(genetics)
- Bacterial Proteins
(genetics)
- Enterobacteriaceae
(genetics)
- Escherichia coli
(genetics)
- Gene Expression Regulation
- Genes, Bacterial
- Molecular Sequence Data
- Multigene Family
- Operon
- Salmonella typhimurium
(genetics)
- Sequence Homology, Nucleic Acid
- Signal Transduction
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