Gentamicin release from biodegradable poly-l-lactide based composites for novel intramedullary nails.

Abstract

One of the major problems in orthopedic surgery is infection associated with implantation. The treatment is a very difficult and long-term process. A solution to this issue can be the use of implants which additionally constitute an antibiotic carrier preventing the development of an infection. Prototypes of biodegradable intramedullary nails made of three different composites with a poly(L-lactide) matrix were designed. The nails served as gentamicin sulfate (GS) carrier - an antibiotic commonly used in the treatment of osteomyelitis. The matrix was reinforced with carbon fibers (CF), alginate fibers (Alg) and magnesium alloy wires (Mg), as well as modified with bioactive particles of tricalcium phosphate (TCP) in various systems. In this way, novel, multi-phase and multifunctional degradable intramedullary nails were obtained. The tests demonstrated strong dependence between the type of the modifying phase introduced into the composite, and the rate of drug release. Introduction of gentamicin into the nail structure strengthened and prolonged antibacterial activity of the nails.

• Authors: Anna Morawska-Chochół, Patrycja Domalik-Pyzik, Jan Chłopek, Barbara Szaraniec, Jacek Sterna, Magdalena Rzewuska, Maciej Boguń, Rafael Kucharski, Przemysław Mielczarek
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 45 Pg. 15-20 (Dec 2014) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 25491796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Alginates
• Alloys
• Anti-Bacterial Agents
• Biocompatible Materials
• Calcium Phosphates
• Gentamicins
• Hexuronic Acids
• Polyesters
• poly(lactide)
• Glucuronic Acid
• tricalcium phosphate

Topics

• Alginates (chemistry)
• Alloys (chemistry)
• Anti-Bacterial Agents (administration & dosage, chemistry, pharmacology)
• Biocompatible Materials (chemistry)
• Bone Nails (microbiology)
• Calcium Phosphates (chemistry)
• Gentamicins (administration & dosage, chemistry, pharmacology)
• Glucuronic Acid (chemistry)
• Hexuronic Acids (chemistry)
• Humans
• Microscopy, Electron, Scanning
• Osteomyelitis (drug therapy, prevention & control)
• Polyesters (chemistry)
• Prostheses and Implants
• Staphylococcus (drug effects)