Abstract | AIM: METHODS: RESULTS:
Nicotinic acetylcholine receptor α4 and β2 subunits were up-regulated in injured nerves and were expressed on F4/80-positive macrophages. When nicotine was perineurally administered daily for 4 days (day 7-10; maintenance phase) after nerve injury, pain behaviours were significantly alleviated. The inhibitory effects of nicotine were reversed by co-administration of mecamylamine (non-selective nicotinic acetylcholine receptor antagonist) and dihydro-β-erythroidine (selective α4β2 nicotinic acetylcholine receptor antagonist). Likewise, when α4β2 nicotinic acetylcholine receptor agonists ( TC2559 or ABT418) were administered daily for 4 days (day 7-10) after nerve injury, pain behaviours were significantly attenuated. On the other hand, nicotine administered daily for 4 days (day 0-3; initiation phase) after nerve injury alleviated pain behaviours, which were antagonized by co-administration of dihydro-β-erythroidine. TC2559 administered daily for 4 days (day 0-3) also attenuated nerve injury-induced pain behaviours. CONCLUSION:
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Authors | F Saika, N Kiguchi, Y Kobayashi, S Kishioka |
Journal | Acta physiologica (Oxford, England)
(Acta Physiol (Oxf))
Vol. 213
Issue 2
Pg. 462-71
(Feb 2015)
ISSN: 1748-1716 [Electronic] England |
PMID | 25491757
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd. |
Chemical References |
- Analgesics
- Receptors, Nicotinic
- nicotinic receptor alpha4beta2
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Topics |
- Analgesics
(pharmacology)
- Animals
- Disease Models, Animal
- Hyperalgesia
(metabolism)
- Male
- Mice, Inbred C57BL
- Neuralgia
(diagnosis, metabolism)
- Peripheral Nerve Injuries
(drug therapy, metabolism)
- Receptors, Nicotinic
(metabolism)
- Sciatic Nerve
(drug effects, metabolism)
- Signal Transduction
(drug effects)
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