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DisABLing kidney cancers caused by fumarate hydratase mutations.

Abstract
Reprogramming of cellular metabolism by oncogenic mutations probably creates specific vulnerabilities that could be exploited therapeutically. In this issue of Cancer Cell, Sourbier and colleagues show that kidney cancers lacking fumarate hydratase display increased sensitivity to agents that interfere with their ability to cope with reactive oxygen species.
AuthorsWilliam G Kaelin Jr
JournalCancer cell (Cancer Cell) Vol. 26 Issue 6 Pg. 779-780 (Dec 08 2014) ISSN: 1878-3686 [Electronic] United States
PMID25490441 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Piperidines
  • Quinazolines
  • Proto-Oncogene Proteins c-abl
  • Fumarate Hydratase
  • vandetanib
Topics
  • Animals
  • Fumarate Hydratase (deficiency)
  • Humans
  • Kidney Neoplasms (drug therapy)
  • Oxidative Stress (drug effects)
  • Piperidines (pharmacology)
  • Proto-Oncogene Proteins c-abl (metabolism)
  • Quinazolines (pharmacology)

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