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NAD(+) supplementation as a novel approach to cURIng HCC?

Abstract
In this issue of Cancer Cell, Tummala and colleagues demonstrate that unconventional prefoldin RPB5 interactor (URI) expression in hepatocytes leads to hepatocellular carcinoma (HCC) development by interacting with L-tryptophan/kynurenine/nicotinamide adenine dinucleotide (NAD(+)) metabolism. The results suggest that supplementation of NAD(+) may be a prophylactic or therapeutic approach in HCC.
AuthorsIngmar Mederacke, Robert F Schwabe
JournalCancer cell (Cancer Cell) Vol. 26 Issue 6 Pg. 777-778 (Dec 08 2014) ISSN: 1878-3686 [Electronic] United States
PMID25490440 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Intracellular Signaling Peptides and Proteins
  • Repressor Proteins
  • URI1 protein, human
  • Uri1 protein, mouse
  • NAD
Topics
  • Animals
  • Carcinoma, Hepatocellular (pathology)
  • DNA Damage
  • Humans
  • Intracellular Signaling Peptides and Proteins (metabolism)
  • Liver Neoplasms (pathology)
  • NAD (metabolism)
  • Repressor Proteins (metabolism)

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