Abstract |
Angiosarcoma is a rare and aggressive type of sarcoma, and primary angiosarcoma of the ovary is extremely rare. We report the case of a 29-year-old woman who was diagnosed with ovarian angiosarcoma and possible bone metastases. We treated this patient with a gemcitabine-based regimen as postoperative adjuvant chemotherapy, after which she achieved at least 7 years of progression-free survival, an extremely long duration given the aggressive features of this tumour. We retrospectively performed immunohistochemical analyses and fluorescence in situ hybridization to make a pathology diagnosis and to investigate the tumour features. MYC amplification and c-Myc protein overexpression were positively detected. It might be possible to correlate the effectiveness of the gemcitabine-based chemotherapeutic regimen with MYC gene amplification and c-Myc protein overexpression.
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Authors | I Yonezawa, M Waki, Y Tamura, R Onoda, M Narushima, T Ishizuka, S Tajima |
Journal | Current oncology (Toronto, Ont.)
(Curr Oncol)
Vol. 21
Issue 6
Pg. e782-9
(Dec 2014)
ISSN: 1198-0052 [Print] Switzerland |
PMID | 25489268
(Publication Type: Journal Article)
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