Abstract |
The effects on general and bone metabolism of femoral neck fracture patients of 0.25 micrograms alpha-calcoid given orally twice daily (n = 9) and 25 micrograms calcitonin given subcutaneously 30 times (n = 10) in 10 weeks were studied against a control (n = 11). Bone histology and histomorphometry showed non- age related osteoporosis in 30% and osteomalacia in 22% of the patients studied. Impaired serum vitamin D status was found in 47-88% of patients, secondary hyperparathyroidism and increased serum parathyroid hormone in 59% and decreased serum calcitonin levels in 69%. On histology, normal findings and non- age related osteoporosis on histology were associated with low serum levels of 25-hydroxyvitamin D3, 1,25- and 24,25-dihydroxyvitamin D3. Very high serum levels of 1,25-dihydroxyvitamin D3 and low levels of 25-hydroxyvitamin D3 occurred in fracture patients with osteomalacia. Calcitonin improved calcium balance, reduced osteoporosis and increased the serum 1,25- and 24,25-dihydroxyvitamin D3 levels but had no effect on osteomalacia. Vitamin D reduced osteomalacia, slightly increased the serum 1,25-dihydroxyvitamin D3 concentration and decreased serum levels of parathyroid hormone. Both treatments gave a similar slight decrease in serum calcitonin concentrations. A mechanism of action for the treatments is suggested.
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Authors | E Harju, R Punnonen, R Tuimala, J Salmi, I Paronen |
Journal | The Journal of international medical research
(J Int Med Res)
1989 May-Jun
Vol. 17
Issue 3
Pg. 226-42
ISSN: 0300-0605 [Print] England |
PMID | 2548905
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Hormones
- Cholecalciferol
- Calcitonin
- Calcifediol
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Topics |
- Aged
- Calcifediol
(therapeutic use)
- Calcitonin
(therapeutic use)
- Cholecalciferol
(blood)
- Clinical Trials as Topic
- Drug Therapy, Combination
- Femoral Neck Fractures
(blood, drug therapy, pathology)
- Hormones
(blood)
- Humans
- Osteomalacia
(blood, pathology)
- Osteoporosis
(blood, pathology)
- Prospective Studies
- Reference Values
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