Abstract | BACKGROUND: METHODS: We searched the PubMed, EMBASE and Cochrane library databases for randomized controlled trial (RCT) and comparative studies reporting use of vitamin C to prevent distal radius fracture. Dichotomous variable was presented as risk ratio with 95 % confidence intervals. RESULTS: We obtained 220 articles from the database search. After the exclusion of duplicates, unrelated articles, letter to editor and editorials, we found four articles relevant to our topic. Meta-analysis of the CRPS incidence revealed that the incidence of CRPS was significantly lower in the vitamin C group [RD 0.41 (0.19-0.92), P = 0.03]. There was moderate to high heterogeneity in the studies included I (2) = 63 %). CONCLUSIONS: Our analysis showed a significant reduction in prevalence of CRPS with the use of vitamin C. Further high-quality RCTs with standard dosages and common diagnostic criteria are needed to be able to deliver solid conclusions.
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Authors | Sanjay Meena, Pankaj Sharma, Shreesh Kumar Gangary, Buddhadev Chowdhury |
Journal | European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
(Eur J Orthop Surg Traumatol)
Vol. 25
Issue 4
Pg. 637-41
(May 2015)
ISSN: 1432-1068 [Electronic] France |
PMID | 25488053
(Publication Type: Journal Article, Meta-Analysis, Review)
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Chemical References |
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Topics |
- Analgesics
(therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Complex Regional Pain Syndromes
(prevention & control)
- Humans
- Middle Aged
- Radius Fractures
(complications)
- Randomized Controlled Trials as Topic
- Risk Factors
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