Abstract | BACKGROUND: HYPOTHESIS: METHODS: Patients enrolled in CRISP-AMI were included in the current analysis. Processes of care during reperfusion were recorded prospectively and compared between groups. RESULTS: A total of 337 patients with anterior STEMI without cardiogenic shock were randomized in CRISP-AMI. Complete processes-of-care data were available for 303 patients (89.9%). In this cohort, 68.0% of patients underwent reperfusion within 90 minutes of hospital contact, and the median D2B time was 71 minutes. Time from hospital contact to informed consent was significantly different across different regions (North America, 45 minutes; India, 35 minutes; Europe, 20 minutes). CONCLUSIONS: In CRISP-AMI, reperfusion was accomplished in a timely fashion while incorporating informed consent and randomization among patients with anterior myocardial infarction. Further study of patients' comprehension and preferences during the informed-consent process in STEMI patients is warranted so that innovative drugs and devices can be safely and ethically tested.
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Authors | W Schuyler Jones, Robert M Clare, Karen Chiswell, Divaka Perera, John K French, A Sreenivas Kumar, Jonathan Blaxill, Nico Pijls, James Mills, E Magnus Ohman, Manesh R Patel |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 38
Issue 1
Pg. 25-31
(Jan 2015)
ISSN: 1932-8737 [Electronic] United States |
PMID | 25488040
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Wiley Periodicals, Inc. |
Topics |
- Aged
- Blood Pressure
- Coronary Angiography
- Coronary Circulation
- Electrocardiography
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Myocardial Infarction
(diagnosis, therapy)
- Myocardial Reperfusion
- Percutaneous Coronary Intervention
(methods)
- Prospective Studies
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