Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77.

Abstract

Lycorine, a natural alkaloid, has been widely reported to possess potential efficacy against cancer. However, the anti-multiple myeloma mechanism of lycorine is not fully understood. In this study, the results demonstrated that lycorine is effective against multiple myeloma cell line ARH-77 via inducing programmed necrosis. The mechanisms of lycorine on the multiple myeloma cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage. Our results elucidate the new mechanism of lycorine against multiple myeloma.

• Authors: Yuhao Luo, Mridul Roy, Xiaojuan Xiao, Shuming Sun, Long Liang, Huiyong Chen, Yin Fu, Yang Sun, Min Zhu, Mao Ye, Jing Liu
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 4 Pg. 2937-45 (Apr 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25487618 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amaryllidaceae Alkaloids
• Phenanthridines
• Proto-Oncogene Proteins c-bcl-2
• Reactive Oxygen Species
• Caspases
• lycorine

Topics

• Amaryllidaceae Alkaloids (administration & dosage, chemistry)
• Apoptosis (drug effects)
• Caspases (biosynthesis)
• Cell Line, Tumor
• DNA Damage (drug effects)
• Humans
• Mitochondria (drug effects, genetics)
• Multiple Myeloma (drug therapy, genetics, pathology)
• Necrosis (chemically induced, pathology)
• Phenanthridines (administration & dosage, chemistry)
• Proto-Oncogene Proteins c-bcl-2 (biosynthesis)
• Reactive Oxygen Species (metabolism)