Loss of calcitonin receptors: a genetically transmitted defect in rats with high incidence of C-cell tumors.

Abstract

C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.

• Authors: Z Bouizar, S Minvielle, F Treilhou-Lahille, W H Rostene, E Pidoux, N Feingold, G Milhaud, M S Moukhtar
• Journal: Cancer research (Cancer Res) Vol. 49 Issue 18 Pg. 5199-202 (Sep 15 1989) ISSN: 0008-5472 [Print] United States
• PMID: 2548716 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Receptors, Calcitonin
• Receptors, Cell Surface
• Calcitonin
• Calcium

Topics

• Aging
• Animals
• Autoradiography
• Calcitonin (metabolism)
• Calcium (pharmacology)
• Chromosome Deletion
• Crosses, Genetic
• Genes
• Iodine Radioisotopes
• Kidney Medulla (metabolism)
• Rats
• Rats, Inbred Strains
• Receptors, Calcitonin
• Receptors, Cell Surface (analysis, genetics)
• Species Specificity
• Thyroid Gland (metabolism)
• Thyroid Neoplasms (genetics)