The epidemiological impact of HIV antiretroviral therapy on malaria in children.

Abstract

OBJECTIVE:

The objective of this study is to determine the epidemiological effectiveness of a first-line antiretroviral regimen with HIV protease inhibitor for preventing recurrent malaria in children under the range of HIV prevalence levels and malaria transmission intensities encountered in sub-Saharan Africa.

DESIGN:

A dynamic model of malaria transmission was developed using clinical data on the protease inhibitor extended posttreatment prophylactic effect of the antimalarial treatment, artemether-lumefantrine, in addition to parameter estimates from the literature.

METHODS:

To evaluate the benefits of HIV protease inhibitors on the health burden of recurrent malaria among children, we constructed a dynamic model of malaria transmission to both HIV-positive and HIV-negative children, parameterized by data from a recent clinical trial. The model was then evaluated under varying malaria transmission and HIV prevalence settings to determine the health benefits of HIV protease inhibitors in the context of artemether-lumefantrine treatment of malaria in children.

RESULTS:

Comparing scenarios of low, intermediate and high newborn HIV prevalence, in a range of malaria transmission settings, our dynamic model predicts that artemether-lumefantrine with HIV protease inhibitor based regimens prevents 0.03-0.10, 5.2-13.0 and 25.5-65.8 annual incidences of malaria per 1000 children, respectively. In addition, HIV protease inhibitors save 0.002-0.006, 0.22-0.8, 1.04-4.3 disability-adjusted life-years per 1000 children annually. Considering only HIV-infected children, HIV protease inhibitors avert between 278 and 1043 annual incidences of malaria per 1000 children.

CONCLUSION:

The use of HIV protease inhibitor based regimens as first-line antiretroviral therapy for HIV is an effective measure for reducing recurrent malaria among HIV-infected children in areas where HIV and malaria are coendemic, and artemether-lumefantrine is a first-line antimalarial.

• Authors: Scott Greenhalgh, Martial Ndeffo, Alison P Galvani, Sunil Parikh
• Journal: AIDS (London, England) (AIDS) Vol. 29 Issue 4 Pg. 473-82 (Feb 20 2015) ISSN: 1473-5571 [Electronic] England
• PMID: 25486414 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antimalarials
• Artemether, Lumefantrine Drug Combination
• Artemisinins
• Drug Combinations
• Ethanolamines
• Fluorenes
• HIV Protease Inhibitors

Topics

• Africa South of the Sahara (epidemiology)
• Animals
• Antimalarials (therapeutic use)
• Artemether, Lumefantrine Drug Combination
• Artemisinins (therapeutic use)
• Child
• Child, Preschool
• Drug Combinations
• Ethanolamines (therapeutic use)
• Fluorenes (therapeutic use)
• HIV Infections (drug therapy, epidemiology, immunology)
• HIV Protease Inhibitors (therapeutic use)
• Humans
• Malaria (drug therapy, epidemiology, prevention & control)
• Recurrence
• Treatment Outcome