Anticancer agents targeted to sirtuins.

Abstract

Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1-7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment.

• Authors: Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Naomichi Arima, Shin-ichiro Honda, Shinji Soeda
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 19 Issue 12 Pg. 20295-313 (Dec 04 2014) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 25486244 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Enzyme Activators
• Histone Deacetylase Inhibitors
• Isoenzymes
• Sirtuins

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Cell Death (drug effects, genetics)
• Enzyme Activators (chemistry, pharmacology)
• Histone Deacetylase Inhibitors (chemistry, pharmacology, therapeutic use)
• Humans
• Isoenzymes
• Neoplasms (genetics, metabolism)
• Sirtuins (antagonists & inhibitors, chemistry, metabolism)