Tecemotide: an antigen-specific cancer immunotherapy.

Abstract

The identification of tumor-associated antigens (TAA) has made possible the development of antigen-specific cancer immunotherapies such as tecemotide. One of those is mucin 1 (MUC1), a cell membrane glycoprotein expressed on some epithelial tissues such as breast and lung. In cancer, MUC1 becomes overexpressed and aberrantly glycosylated, exposing the immunogenic tandem repeat units in the extracellular domain of MUC1. Designed to target tumor associated MUC1, tecemotide is being evaluated in Phase III clinical trials for treatment of unresectable stage IIIA/IIIB non-small cell lung cancer (NSCLC) as maintenance therapy following chemoradiotherapy. Additional Phase II studies in other indications are ongoing. This review discusses the preclinical and clinical development of tecemotide, ongoing preclinical studies of tecemotide in human MUC1 transgenic mouse models of breast and lung cancer, and the potential application of these models for optimizing the timing of chemoradiotherapy and tecemotide immunotherapy to achieve the best treatment outcome for patients.

• Authors: Gregory T Wurz, Chiao-Jung Kao, Michael Wolf, Michael W DeGregorio
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 10 Issue 11 Pg. 3383-93 ( 2014) ISSN: 2164-554X [Electronic] United States
• PMID: 25483673 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, Neoplasm
• Cancer Vaccines
• L-BLP25
• MUC1 protein, human
• Membrane Glycoproteins
• Mucin-1

Topics

• Animals
• Antigens, Neoplasm (immunology)
• Breast Neoplasms (immunology, therapy)
• Cancer Vaccines (therapeutic use)
• Carcinoma, Non-Small-Cell Lung (immunology, therapy)
• Chemoradiotherapy
• Disease Models, Animal
• Female
• Humans
• Immunotherapy (methods)
• Lung Neoplasms (immunology, therapy)
• Membrane Glycoproteins (therapeutic use)
• Mice
• Mice, Transgenic
• Mucin-1 (immunology)