Interleukin-22 and rheumatoid arthritis: emerging role in pathogenesis and therapy.

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and resultant progressive joint damage. It has become increasingly evident that cytokines play an important role in the pathogenesis of RA. Interleukin-22 (IL-22) is a member of the IL-10 cytokine family. Recent findings suggest that not only the expression of IL-22 is abnormal both in RA patients and in arthritis mice but also the aberrant IL-22 performs significantly in disease onset of RA. In this paper, we focus on the critical role of IL-22 in RA. Hopefully, the information obtained may lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for this systemic autoimmune disease.

• Authors: Qiang Xie, Cheng Huang, Jun Li
• Journal: Autoimmunity (Autoimmunity) Vol. 48 Issue 2 Pg. 69-72 (Mar 2015) ISSN: 1607-842X [Electronic] England
• PMID: 25483133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Autoantibodies
• IL10 protein, human
• Interleukins
• Interleukin-10
• interleukin-22

Topics

• Animals
• Arthritis, Rheumatoid (genetics, immunology, pathology, therapy)
• Autoantibodies (biosynthesis)
• Disease Progression
• Gene Expression
• Humans
• Interleukin-10 (genetics, immunology)
• Interleukins (genetics, immunology, pharmacology)
• Joints (drug effects, immunology, metabolism, pathology)
• Mice
• Signal Transduction