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Baicalein pretreatment protects against liver ischemia/reperfusion injury via inhibition of NF-κB pathway in mice.

Abstract
Ischemia/reperfusion (I/R) is a pathophysiologic process that occurs during hemorrhagic shock, liver resection and liver transplantation. Baicalein, the main active ingredient of the Scutellaria root, exerts anti-inflammatory and anti-apoptotic properties in the setting of I/R injury in the heart and brain. However, the role of baicalein in liver I/R injury and its regulatory mechanisms remain poorly understood. This study was designed to evaluate the effects of baicalein in a model of liver I/R in mice and to explore the possible mechanisms. Baicalein (100mg/kg) was intraperitoneally injected 1h before warm ischemia. Pretreatment with baicalein protected against liver I/R injury, as indicated by the decreased serum aminotransferase levels and the reduced histopathologic abnormalities. Baicalein also significantly reduced cellular hepatic apoptosis in response to I/R injury. Moreover, pretreatment with baicalein significantly inhibited nuclear factor-kappa B (NF-κB) activation and the subsequent proinflammatory cytokine production, and decreased leukocyte infiltration. In vitro studies, baicalein treatment inhibited the proinflammatory cytokine production via the modulation of NF-κB signaling pathway in lipopolysaccharide-stimulated macrophages. Taken together, these results suggest that baicalein could protect against liver I/R injury via inhibition of inflammation by down-regulating NF-κB activity, and suppression of cellular hepatic apoptosis.
AuthorsAnding Liu, Liang Huang, Hua Fan, Haoshu Fang, Yan Yang, Shenpei Liu, Jifa Hu, Qi Hu, Olaf Dirsch, Uta Dahmen
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 24 Issue 1 Pg. 72-9 (Jan 2015) ISSN: 1878-1705 [Electronic] Netherlands
PMID25479717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Antioxidants
  • Flavanones
  • Lipopolysaccharides
  • NF-kappa B
  • baicalein
  • Creatinine
  • Alanine Transaminase
Topics
  • Alanine Transaminase (blood)
  • Animals
  • Antioxidants (administration & dosage)
  • Apoptosis (drug effects)
  • Cell Line
  • Creatinine (blood)
  • Flavanones (administration & dosage)
  • Hepatocytes (drug effects, pathology)
  • Lipopolysaccharides (metabolism)
  • Liver (blood supply, drug effects)
  • Macrophages (drug effects, immunology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B (antagonists & inhibitors)
  • Reperfusion Injury (prevention & control)
  • Signal Transduction (drug effects)

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