Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage.

Abstract

Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS)-induced cell death and stimulate proliferation due to the antioxidative property of these particles.

• Authors: Claudia von Montfort, Lirija Alili, Sarah Teuber-Hanselmann, Peter Brenneisen
• Journal: Redox biology (Redox Biol) Vol. 4 Pg. 1-5 ( 2015) ISSN: 2213-2317 [Electronic] Netherlands
• PMID: 25479549 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Reactive Oxygen Species
• Cerium
• ceric oxide

Topics

• Cell Proliferation (drug effects)
• Cerium (administration & dosage, adverse effects)
• Fibroblasts (drug effects)
• Humans
• Nanoparticles (administration & dosage, adverse effects)
• Neoplasm Invasiveness (pathology, prevention & control)
• Oxidation-Reduction (drug effects)
• Reactive Oxygen Species (toxicity)
• Skin Neoplasms (drug therapy, pathology)