Urinary incontinence and lower urinary tract dysfunction, whilst not life threatening conditions, remain an important cause of morbidity in women and are responsible for significant impairment of quality of life.
Drug therapy is often used to treat women who complain of urgency and
urge incontinence and has an emerging role in the management of
stress urinary incontinence. However, bothersome side effects are known to affect compliance and therefore compromise efficacy, making longterm
drug therapy unpopular. The principle aim of this thesis is to assess the role of antidiuresis in women complaining of
daytime urinary incontinence and also to examine its role as a 'designer
therapy' which women can choose to use as, or when, required. In addition both the patients' and clinicians' attitudes towards treatment have been studied to clarify the meaning of 'cure', and to determine treatment acceptability, overall outcome and patient satisfaction. In the first study the patients' concept of cure is explored as well as their expectations regarding treatment and outcome. The second study examines cure from the clinician's perspective in addition to reviewing outcome measures in the clinical and research settings. Finally in the third study the use of
desmopressin in women complaining of
daytime urinary incontinence is reported.