Hepatocyte growth factor: A regulator of inflammation and autoimmunity.

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.

• Authors: Nicolas Molnarfi, Mahdia Benkhoucha, Hiroshi Funakoshi, Toshikazu Nakamura, Patrice H Lalive
• Journal: Autoimmunity reviews (Autoimmun Rev) Vol. 14 Issue 4 Pg. 293-303 (Apr 2015) ISSN: 1873-0183 [Electronic] Netherlands
• PMID: 25476732 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Hepatocyte Growth Factor

Topics

• Animals
• Autoimmunity
• Hepatocyte Growth Factor (metabolism)
• Humans
• Inflammation (immunology)
• Signal Transduction