Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity.

Abstract

This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.

• Authors: Dawei Xu, Linhai Jiang, Anju Singh, Derek Dustin, Miao Yang, Ling Liu, Reidar Lund, Timothy J Sellati, He Dong
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 7 Pg. 1289-92 (Jan 25 2015) ISSN: 1364-548X [Electronic] England
• PMID: 25476705 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Peptides

Topics

• Amino Acid Sequence
• Animals
• Anti-Bacterial Agents (chemistry, pharmacology, toxicity)
• Bacteria (drug effects)
• Bone Marrow Cells (cytology)
• Cell Survival (drug effects)
• Drug Design
• Mice
• Models, Molecular
• Monocytes (cytology, drug effects)
• Nanostructures
• Peptides (chemistry, pharmacology, toxicity)
• Protein Conformation