Abstract | OBJECTIVES: STUDY DESIGN: A total of 58 keratin-producing odontogenic cysts, diagnosed over ten years and classified according to the WHO 2005 criteria, were immunohistochemically analyzed in terms of CCD1 expression, which was quantified in the basal, suprabasal and intermediate/superficial epithelial compartments. The extent of immunostaining was measured as a proportion of total epithelial thickness. Quantified immunohistochemical data were correlated with clinicopathological features and clinical recurrence. RESULTS:
Keratin-producing odontogenic cysts were classified as 6 syndromic keratocystic odontogenic tumors (S-KCOT), 40 sporadic or non-syndromic KCOT (NS-KCOT) and 12 orthokeratinized odontogenic cysts (OOC). Immunohistochemically, CCD1 staining was evident predominantly in the parabasal region of all cystic lesions, but among-lesion differences were apparent, showing a clear expansion of parabasal compartment especially in the S-KCOT, followed to a lesser extent in the NS-KCOT, and being much more reduced in the OOC, which had the greatest average epithelial thickness. CONCLUSIONS: The differential expression of CCD1 noted in the present study suggests that dysregulation of cell cycle progression from G1 to the S phase contributes to the different aggressiveness of these lesions. However, CCD1 expression levels did not predict NS-KCOT recurrence, which is likely influenced by factors unrelated to lesion biology.
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Authors | Beatriz Vera-Sirera, Leopoldo Forner-Navarro, Francisco Vera-Sempere |
Journal | Medicina oral, patologia oral y cirugia bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 20
Issue 1
Pg. e59-65
(Jan 01 2015)
ISSN: 1698-6946 [Electronic] Spain |
PMID | 25475773
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Cyclin D1
(biosynthesis)
- Female
- Humans
- Jaw Diseases
(metabolism)
- Keratins
(biosynthesis)
- Male
- Middle Aged
- Odontogenic Cysts
(metabolism)
- Retrospective Studies
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