FTO: linking m6A demethylation to adipogenesis.

Abstract

Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

• Authors: Moshe Shay Ben-Haim, Sharon Moshitch-Moshkovitz, Gideon Rechavi
• Journal: Cell research (Cell Res) Vol. 25 Issue 1 Pg. 3-4 (Jan 2015) ISSN: 1748-7838 [Electronic] England
• PMID: 25475057 (Publication Type: Journal Article, Comment)

Chemical References

• RNA, Messenger
• Mixed Function Oxygenases
• Oxo-Acid-Lyases
• Adenosine

Topics

• Adenosine (analogs & derivatives)
• Adipocytes (cytology)
• Adipogenesis
• Animals
• Mixed Function Oxygenases (metabolism)
• Oxo-Acid-Lyases (metabolism)
• RNA Splicing
• RNA, Messenger (genetics)