The role of screening sinus computed tomography in pediatric hematopoietic stem cell transplant patients.

Abstract

OBJECTIVE:

The objective of this study was to evaluate pretransplant sinus computed tomography (CT) as predictor of post-hematopoietic stem cell transplant sinusitis.

METHODS:

We evaluated pretransplant and posttransplant CT findings in 100 children using the Lund-Mackay system and "common-practice" radiology reporting and correlated these with the presence of acute sinusitis.

RESULTS:

Fourteen percent of patients with normal screening CT developed posttransplant sinusitis, compared with 23% with radiographic abnormalities and 22% with clinical sinusitis alone, not statistically significant. Sensitivity of CT findings for clinical sinusitis ranged between 19% and 56%. Except for mucosal thickening (71% specificity), other findings had high specificity between 92% and 97%, particularly when combined. Lund-Mackay score change of 10 or greater from baseline was associated with a 2.8-fold increased likelihood of having sinusitis (P < 0.001).

CONCLUSIONS:

Screening CT can serve as a baseline, with a Lund-Mackay score change of 10 or greater constituting a significant threshold. The strongest correlation with the presence of acute sinusitis was seen with combined CT findings.

• Authors: Carlos A Zamora, Avi G Oppenheimer, Hema Dave, Heather Symons, Thierry A G M Huisman, Izlem Izbudak
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) Vol. 39 Issue 2 Pg. 228-31 ( 2015) ISSN: 1532-3145 [Electronic] United States
• PMID: 25474147 (Publication Type: Evaluation Study, Journal Article)

Topics

• Adolescent
• Child
• Child, Preschool
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Infant
• Male
• Paranasal Sinuses (diagnostic imaging)
• Postoperative Complications (diagnostic imaging)
• Predictive Value of Tests
• Preoperative Care
• Retrospective Studies
• Sinusitis (diagnostic imaging)
• Tomography, X-Ray Computed
• Young Adult