Abstract | BACKGROUNDS/AIMS: Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients. METHODS: RESULTS AND CONCLUSIONS: MPV was higher in ITP than in HPT patients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
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Authors | Svetlana G Khaspekova, Olga N Shustova, Nina V Golubeva, Sergey A Vasiliev, Alexey V Mazurov |
Journal | Acta haematologica
(Acta Haematol)
Vol. 133
Issue 3
Pg. 295-9
( 2015)
ISSN: 1421-9662 [Electronic] Switzerland |
PMID | 25472766
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Platelet Glycoprotein GPIb-IX Complex
- glycocalicin
- Thrombopoietin
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Topics |
- Adolescent
- Adult
- Anemia, Aplastic
(blood)
- Female
- Humans
- Leukemia
(blood)
- Male
- Mean Platelet Volume
- Middle Aged
- Platelet Glycoprotein GPIb-IX Complex
(metabolism)
- Thrombocytopenia
(blood)
- Thrombopoietin
(blood)
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