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Relationships of mean platelet volume and plasma thrombopoietin with glycocalicin levels in thrombocytopenic patients.

AbstractBACKGROUNDS/AIMS:
Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients.
METHODS:
MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPT patients had PA-IgG <300% and glycocalicin <50% of control values.
RESULTS AND CONCLUSIONS:
MPV was higher in ITP than in HPT patients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
AuthorsSvetlana G Khaspekova, Olga N Shustova, Nina V Golubeva, Sergey A Vasiliev, Alexey V Mazurov
JournalActa haematologica (Acta Haematol) Vol. 133 Issue 3 Pg. 295-9 ( 2015) ISSN: 1421-9662 [Electronic] Switzerland
PMID25472766 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Platelet Glycoprotein GPIb-IX Complex
  • glycocalicin
  • Thrombopoietin
Topics
  • Adolescent
  • Adult
  • Anemia, Aplastic (blood)
  • Female
  • Humans
  • Leukemia (blood)
  • Male
  • Mean Platelet Volume
  • Middle Aged
  • Platelet Glycoprotein GPIb-IX Complex (metabolism)
  • Thrombocytopenia (blood)
  • Thrombopoietin (blood)

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