Polymorphisms in
interleukin (IL)-4/
IL-13 pathway genes have previously been reported to be associated with
glioma susceptibility, although results are inconsistent. We therefore performed an updated meta-analysis to determine a more precise estimation of this relationship. Twelve eligible studies were identified by searching PubMed, EMBASE, Web of Science, and the Cochrane Library electronic databases. Nine polymorphisms in genes within the IL-4/
IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and
IL-13 rs20541 and rs1800925) were assessed for their relationship with
glioma risk by computing odds ratios (
ORs) and corresponding 95 % confidence intervals (CIs). Akaike's information criterion (AIC) was used to identify the best genetic model for each polymorphism. No association between IL-4/
IL-13 pathway genetic polymorphisms and
glioma risk was observed in the overall population, although a significant association was found between rs2234248 and
glioblastoma when stratified by histological subtype (log-additive model, OR 1.57, 95 % CI 1.11-2.24). This meta-analysis therefore suggested that IL-4/
IL-13 pathway genetic polymorphisms are not associated with
glioma risk.